A comprehensive analysis of HIV treatment
For the prevention of viral diseases, human first thought of a vaccine against HIV is no exception.Unfortunately, the human AIDS vaccine research and development on a journey filled with failure.Merck developed in 10 years, called V520’s AIDS vaccine, had been high hopes for the medical profession.In 2004, by Merck, the U.S. National Institute of Allergy and Infectious Diseases, and an HIV vaccine, called the League of academic institutions in the composition of the team will begin to implement a global trial called STEP.However, the September 18, 2007, the three parties announced the suspension of the history of the first AIDS vaccine clinical trials.
According to the United Kingdom in April this year, “The Independent” A 36 top scientists investigating HIV, most of the scientists involved in AIDS research that is now the prospect of development of HIV vaccines than ever before are pessimistic, some scientists have even admitted that, perhaps never may develop an effective AIDS vaccine.
The reason, HIV variation complexity of existence, the characteristics of a high mutation rate, which is the biggest obstacle to vaccine development.A high degree of HIV genome variability, can easily mutate strain, HIV major surface glycoprotein epitope is also extremely variable, different countries and regions of the HIV subtypes are also different.In short, HIV is like a constantly moving through the activities of target and trajectory are subject to change hastily shot is not the center of bull’s-eye.
HIV vaccine research and development scientists are at the darkest era of AIDS, another reason is that, HIV pathogenesis and immune mechanism has not yet entirely clear.In other words, human beings still do not find out the aspects of this piece of moving target, naturally can not find best of the best ways to prevent the AIDS vaccine research and development.
At present, the world has not yet cured AIDS represent good policy.HIV infection is the most frequently used highly active antiretroviral therapy (HAART), commonly known as “cocktail therapy.”
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70% AIDS patients are treated through cocktail therapy for 3-6 months, peripheral blood detected on HIV, viral load close to zero.This year in July, “The Lancet” magazine published in Europe and North America led to a large-scale cohort study.The study found that the cocktail since the application has been, HIV carriers and AIDS patients has been an average extension of life expectancy of 13.8 years, the patient survival rate of increase in AIDS mortality also significantly dropped by nearly 40%.
Cocktail therapy is not perfect.It the early AIDS patients in more effective and not very helpful for the terminally ill, HIV causes the immune system has been defeated, and irreversible.This therapy is costly to spend a year at least ten thousand dollars, not ordinary people can afford.Have used any drug side-effects, this therapy is no exception.
In China, Beijing Union Medical College Hospital Professor Li Taisheng organized and completed a national “15″ science and technology research programs topic “China’s AIDS patients antiretroviral therapy,” the first time that the efficacy of home-made anti-viral drugs in line with similar imported, adverse reactions rates are equivalent, but the price is only one-sixth of imported drugs, the study results was also selected in 2006 China’s top ten technology news.
Bone Marrow Transplantation
At present the most sensational of the treatment is bone marrow transplantation.
In November 2008, Germany Berlin, check Reiter School of Medicine (Charité Medical University), announced at the same time suffering from AIDS and leukemia, an American man, receiving the original treatment of leukemia bone marrow transplant 20 months after the mysterious disappearance of HIV in vivo.
